Chronobiotics KL001 and KS15 Extend Lifespan and Modify Circadian Rhythms of Drosophila melanogaster

Chronobiotics are a group of drugs, which utilized to modify circadian rhythms targeting clock-associated molecular mechanisms. The clock is known as controller numerous processes in connection with aging. Hypothesis: KL001 and KS15 CRY, affect lifespan, locomotor activity rhythm Drosophila melanogaster. We observed slight (2%, p < 0.001) geroprotective effect on median lifespan (5 µM solution 0.1% DMSO) 14% increase maximum the same group. 10 extended males’ by 8% (p 0.05). statistically significant positive effects were not female flies. 5 improved young male imagoes 0.05), elevated morning peak aged modified robustness their rhythms, leaving period intact. decreased constant darkness minimized number rhythmic 9% mean starvation resistance flies 0.01), while was 50% 0.0001). This phenomenon may suggest presence mechanism associated improvement fat body glucose depos’ utilization conditions activated dCRY binding KL001.